Nicastrin guards Alzheimer’s gate

Nicastrin guards Alzheimer's gate.

Alzheimer’s disease is characterized by protein deposits of amyloid-β as plaques in the brain (1). The suite of enzymes that produce amyloid-β by cutting it out of the amyloid-β precursor protein (APP) have long been considered to be prime targets for therapeutic intervention. Converting this promise into reality, however, continues to be stalled by a series of obstacles, including an inaccurat...

Guards at the Gate to Embryonic Stem Cell Differentiation

A core network of genes maintaining pluripotency has been at least partially defined. How the genetic switch is flipped to differentiation is the subject of a new study that reveals some unexpected players.

Schedulability Analysis for Guards Computational Models Guards D1a4/ao/7013b

Motivating lazy guards

Workflow Data Guards

Workflow management systems (WfMSs) frequently use data to coordinate the execution of workflow instances. A WfMS evaluates conditions defined on data to make the control flow decisions i.e. selecting the next activity or deciding on an actor. However, data within and outside of a running workflow instance may change dynamically. Modifications of data needed for past control flow decisions may ...